They will kill any rapidly dividing cell, tumor or normal. Conditioning regimens are used to suppress the recipient's immune system in order to allow a transplant to engraft. "Overcoming chemoresistance has been extensively studied within the past, especially using CDDP-resistant cells. [66], There are many intravenous methods of drug delivery, known as vascular access devices. This causes kidney damage and the high levels of potassium can cause cardiac arrhythmia. 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Hence, greater effectiveness of antitumor treatment is achieved. As for mine and yours, chemotherapy was shown to be 1.8% effective toward 5-year survival for colon cancer and 5.4% effective for rectal cancer. [98] Not all of this increase can be attributed to chemotherapy. [58], The cytotoxic antibiotics are a varied group of drugs that have various mechanisms of action. [62], Actinomycin is a complex molecule that intercalates DNA and prevents RNA synthesis. The newly formed tumor vasculature is poorly formed and does not deliver an adequate blood supply to all areas of the tumor. (In autologous BMTs, cells are removed from the person before the treatment, multiplied and then re-injected afterward; in allogenic BMTs, the source is a donor.) Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer [105] Second- and third-trimester exposure does not usually increase the teratogenic risk and adverse effects on cognitive development, but it may increase the risk of various complications of pregnancy and fetal myelosuppression.
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