Side Effects . Applies to cortisone: oral tablets. Steroid injections often ease inflammation in a joint so it can work better. If you have any side effects, be sure to contact your healthcare provider. The steroids usually begin working within 1 to 3 days. Doctors and patients should beware if they're hoping to use steroid injections to relieve the pain associated with osteoarthritis. Corticosteroids, a type of steroid, are powerful drugs that do a lot of good, but they also come with side effects, including in the eyes. This cortisone shot helps reduce the inflammation, swelling, redness and heat of the tendons, ligaments, or joints. Some doctors often are not keenly aware of the side effects of cortisone as these tend to be limited (they resolve in a short amount of time) and your doctor may not see these effects as they tend to occur long after the patient has left the office. Glaucoma and cataracts are two of the main concerns. Mood Changes Dreamstime. Like any drug, there are possible reactions, side effects, and complications that can occur with a cortisone injection. In some cases, you might need up to a week to feel the benefits. The same study did not find an association with increased knee pain. In the short term, side effects are rare. Cortisone, as mentioned, belongs to a broad class of medications known as corticosteroids. Cardiovascular Local injections are generally well-tolerated and are less likely to produce serious side effects than other forms of steroid medications. For example, one study 6 found an association between repeated cortisone injections and 0.11 cm loss of cartilage in the knee. (See Warnings/Precautions under Cautions.) If the injection is effective, it can be repeated. A cortisone injection is a steroid injection (containing corticosteroid), which mimics the action of cortisol which I produced by the adrenal gland in the human body. Applies to cortisone: compounding powder, injectable suspension, oral tablet. An epidural steroid injection is a common procedure to treat spinal nerve irritation that is most often caused by tissues next to the nerve pressing against it. Steroid injections may help avoid the need for oral steroids or increased doses of oral steroids, which could have greater side effects. Research suggests cortisone injections may have a negative effect on cartilage. Infection. This usually settles on its own within a couple of days but taking simple painkillers like paracetamol will help. This makes them a somewhat risky endeavor. Many people get several months of improvement of pain and function from the injections. Cortisone injection side effects seem to be common when they are used as a treatment for arthritis and in high doses. Local steroid injections are less likely to cause serious side effects than other forms of steroid medications. Steroid injection side-effects. 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